By Louise Gagnon
VIRTUAL -- October 22, 2021 -- Embryos produced from oocytes exposed in vivo to lipid nanoparticles containing mRNA for the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) spike protein are not less likely to produce pregnancy or more likely to miscarry, according to an ongoing observational study presented at the 2021 Annual Meeting of the American Society for Reproductive Medicine (ASRM).
“A fairly significant number of people that are worried about fertility are not getting their [COVID-19] vaccine,” said Randy S. Morris MD, University of Chicago, Naperville, Illinois. “[Our] data refutes the rumors that COVID-19 vaccinations are toxic to the ovaries and adds to the growing body of evidence that vaccinations do not cause infertility.”
The study included 128 women undergoing frozen embryo transfer with a single expanded blastocyst between January 1, 2021, and July 2, 2021. All patients had serum analyzed prior to starting stimulation for egg retrieval to quantitatively determine the level of anti-SARS-CoV-2 Spike IgG. Reactive (antibody positive) patients were questioned to determine a history of vaccination or infection.
Of the women, 26 were vaccinated with the BNT162b2 or mRNA-1273 mRNA COVID-19 vaccines, 11 had a history of previous infection with SARS-CoV-2, and 91 were not vaccinated nor had a history infection.
The primary outcomes were initial implantation rate, sustained implantation rate, and miscarriage rate.
Implantation rate for women with no history of infection or vaccination was 86.8%, compared with 84.6% among women who received an mRNA COVID-19 vaccine, and 90.9% among women with previous infection. Sustained implantation rate was 63.7%, 61.5%, and 54.6%, respectively. The rate of miscarriage was 23.1%, 23.1%, and 36.3%, respectively.
“We’re not seeing any impact [on fertility] because of these vaccines,” said Dr. Morris.
[Presentation title: Exposure of Ovaries to COVID-19 Vaccination Does Not Impair Fertility. Abstract O-190]
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